Isami was bitten by Iwao Maeda and forbid Motoko Maeda to call Toshio Ozaki, but she did it anyway as she was fearing for Shigeki Maeda and Shihori Maeda. Toshio came to their house and examined him, but Isami refused to go to the clinic. Soon after Toshio left, Isami died. He was the second Maeda to die. Toshio later reflected on his refusal to be hospitalized.