|Anime Debut||Episode 3|
|Voice Actor||Judy Keith|
- "Is it you, my Nao?"
- ―Setsuko's last words
Her husband brings her to the Ozaki Clinic.
Setsuko was bitten by her daughter-in-law, Nao Yasumori and many other Shiki, and died despite Toshio Ozaki's efforts to save her life. Like her husband, son and grandson (who were all bitten by Nao), she didn't return to life.
- The name Setsuko means "section, period, verse, melody" (節) (setsu) and "child" (子) (ko).
- Setsuko's surname Yasumori means "peace, quiet" (安) (yasu) and "forest" (森) (mori).